Origin: Anc Greek
In 1938 by Hermann J. Muller, who believed that telocentric chromosomes with centromere terminally located, could not exist in nature. According to Muller’s hypothesis, a chromosome must be quarded by a telomere at both ends to maintain its integrity during cell division.
Telemeres are nucleoprotein structures consisting of repetitive TTAGGG sequences terminate in a 3; single-stranded G-rich overhang. Telomeres are maintained by the enzyme telomerase.