Literally meaning: “the enzyme that breaks down rounds”
Origin: Anc Greek
+(-άση)/(-asy)(=-ase) enzyme suffix added to the name of the substrate that the enzyme hydrolyzes eg proteinase for protein or lipase for lipids
>διά-/dia-(=prefix denoting “through”, “apart” )
> δυο/dio(two) + στάσις/stasis(=halt) > ίστημι/histimi(=stand).
DNA gyrase was discovered and first isolated by Gellert et
al. from E. coli. It has been further studied by this and
other groups and has also been isolated from Micro-
Gellert, M., Mizuuchi, K., O’Dea, M. H., and Nash, H. (1976) Proc. Natl. Acad. Sci. U. S. A. 73, 3872-3876
Gyrase is the enzyme that unwinds the coiled double-stranded DNA in order to relieve tension for helicase.