Literally meaning: “production of new vessels”
Origin: Anc Greek
αγγείο/aggio (=vessel, receptacle) > άγγος/aggos(=tube)
+γένεσις/genesis(=origin) > γεννώ/geno(= “to produce”, “to give birth to”, “to create”)
The term angiogenesis was coined by Arthur T. Hertig in 1935 to describe the formation of new blood vessels in the placenta.
Hertig AT. Angiogenesis in the early human chorion and in the primary placenta of the macaque monkey. Contr Embryol Carnegie Inst. 1935;25:37–81.
Angiogenesis is the process of new vessels formation from pro-existing vessels induced by angiogenic factors. Angiogenesis is opposite to angiostasis (normal regulation of blood vessels) and includes proliferation and migration of endothelial cells. Vasculogenesis includes de-novo formation of new vessels.