Term: dystrophin
Literally
meaning: “malnutrition ”
Origin: Anc Greek
+δυσ-/dys-(=prefix used
with a negative sense meaning “difficult”, “bad”, “abnormal”, “misfortune”) > δύω/dyo(=decline) δύση/dysi(=sundown)
+ τροφή/trophe(=food, nourishment )> δρέπω/drepo(=gather))
Coined/History
In the 1860s
French physician Guillaume Duchenne (1806-1875) noticed that the muscles
in some young boys were weakening as he believed that dystrophy progressed as
muscles continued to develop without the nutrients they needed. In 1987 a
protein was identified that named dystrophin because of its abnormal form
causes muscular dystrophy.
Sourse
Hoffman
E, Brown R, Kunkel L (1987). "Dystrophin: the protein product of the
Duchenne muscular dystrophy locus". Cell 51 (6):
919–28.
Definition
Dystrophin is a large (427kDa) muscle cytoskeleton protein, 3684 aminoacids long,
with significant role in the maintance of cellular structure. In humans, the
absence or abnormality of dystrophin leads to Duchenne or Becker muscular
dystropy.
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