Term:erythropoietin
Literally
meaning: “protein of making erythrocytes”
Origin: Anc Greek
Origin: Anc Greek
ερυθρός/erythros(=red)
+ποιέω/poieo (=create, make)
Coined/History
The concept of
a hormone that regulates red blood cell production was proposed in 1906
by Paul Camot and DeFlandres who observed that serum from anemic donor rabbit
injected into normal rabbits could lead to erythropoiesis.. The name was introduced by Eva Bonsdorff and Eeva Jalavisto, in 1948, after studying red cell
production in animals. Hematologists John Adamson and nephrologist Joseph W
Eschbach looked at the role of the natural hormone EPO in the formation of red
blood cells and could help to a treatment to anaemia. Finally in 1985 the human
erythropoietin gene was cloned by Jacobs et
al., and a large scale production began. In 1987 a clinical trial was
conducted for a synthetic form of the hormone, Epogen produced by Amgen
Sources
1. Carnot M, Deflandre C. Comptes Rendus Hebdomadaires desSeances de
l’Acad des Sci. 1906;143:384-386.
2. Eva Bonsdorff, eeva Jalavisto A Humoral Mechanism in Anoxic Erythrocytosis
Acta
Physiologica Scandinavica, Volume 16, Issue 2-3, pages 150–170, November 1948
3. Eschbach JW, Egrie JC, Downing MR, Browne JK, Adamson JW (January
1987). "Correction of the anemia of end-stage renal disease with
recombinant human erythropoietin. Results of a combined phase I and II clinical
trial". N. Engl. J. Med. 316 (2): 73–8.
4.Jacobs K, Shoemaker C,
Rudersdorf R, et al. Isolation andcharacterization of genomic and cDNA clones
of humanerythropoietin. Nature 1985;313(6005):806-10
Definition
Erythropoetin is a glycoprotein produced by kidney that
stimulates precursor erythrocytes proliferation in bone marrow.
Why would a serum from an anemic (fewer red blood cells) donor rabbit injected into normal rabbits lead to erythropoiesis (more red blood cells)? Doesn't that seem backwards?
ReplyDelete