Term: acanthocyte
Literally
meaning: “thorny
cell”
Origin: Anc Greek
άκανθα/acantha(=thorn, sharp spiny structure)
+κυτο-/cyto- (=-cyte combining form meaning “cell” derived from anc
Greek κυτίον/kytion/cytion=box, container)
Coined/History
The term “acantosytosis” was itself coined in
1950 by Bassen in order to decsribe the
dysmorphic erythrocytes seen in the Bassen-Kornzweig syndrome of fat
malabsorption. Acantocytes in the setting of neurological disorders was first
reported by Rovino and Pirone in 1963.
Sourse
Khalid Al-Shali and Robert
A. Hegele “Acantocytes and Disorders of Lipoprotein Metabolism”
Neuroacnthocytosis syndromes, 2005, part 2.
Definition
Acanthocyte is a type of red blood cell that is
characterised by its thorny appearance caused by proplasmic projections.
Acantocytes are seen in abetalipoproteinemia cirrhosis and other conditions.Up
to 3% acanthocytes in the peripheral blood smear may be considered normal.
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