Term: angiostatin
Literally
meaning: “protein of blocking blood
vessels”
Origin: Anc Greek
αγγείο/angio(=vessel, receptacle) > άγγος/aggos(=tube)
+ίστημι/histimi(=stand) >στάσις/stasis(=halt)
Coined/History
Angiostatin was observed initially in 1994 as an
angiogenesis inhibitor in serum and urine of mice bearing a Lewis lung
carcinoma. The same research group reffered that plasminogen yields distinct
angiostatins which have been termed angiostatin -1 and angiostatin-2.
Sources
O’Reilly M. S., Holmgren L., Shing Y., Chen C., Rosenthal R. A., Moses M. A.,
Lane W. S., Cao Y.,Sage E. H.,Folkman J. (1994) Cell 79:315–328
Definition
An endogenous protein that inhibits endothelial
proliferation and was identified as an 38 kDa internal fragment of plasminogen.
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