Term: creatine kinase or creatine
phosphokinase (CPK)
Literally
meaning: “enzyme
of transfering energy chemical groupto creatine”
Origin: Anc Greek
κρέας/creas (flesh, meat)
+ίνη/-ine(-ine) = chemical suffix
κινώ/kino(=move)
+(-άση)/(-asy)(=-ase) enzyme suffix added to the
name of the substrate that the enzyme
hydrolyzes eg proteinase for protein or lipase for lipids
>διά-/dia-(=prefix denoting “through”, “apart” )
> δυο/dio(two) + στάσις/stasis(=halt)
> ίστημι/histimi(=stand).
Coined/History
Creatine is an organic compound that serves as the energy storage form
of cells mainly in muscle fibers. In 1835 French chemist and philosopher Michel-Eugene Chevreul
(1786-1889) discovered it in the juice of flesh and named by him. Creatine
kinase was first described by Lohmann in 1934 who showed in extracts of skeletal muscle the two labile phosphate
groups of ATP were trransfererred to creatine. The reveraibility of the
reaction was demonstrated by Lohmann (1935) and Banga in 1943 effected a
partial purification of the enzyme .
Sources
1. Lohmann, K. (1934). Biochem. Z. 271, 264
2. Lehmann, H. (1935).
Biochem. Z. 281, 271
3. Banga, I.
(1943). Stud. Inst. med. Chem. Univ. Szeged, 8, 59
Definition
Creatine kinase (CK) is a kinase that converts
creatine to phosphocreatine consuming ATP.
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