Term: pepsin
Literally meaning: “protein of digesting”
Origin: Anc Greek
πέπτω/pepto(=digest)
Coined/History
The term
coined by German physiologist Theodor Schwann in the early 19th century when he
identified a chemical agent in the stomachs of animals with digestive
properties. In 1929 John H. Nortrop was
able to isolate and crystallize it.
Definition
Pepsin is a
proteolytic acidic enzyme (unstable above pH 6) that cleaves the peptide bonds at carboxy site
preferentially of aromatic residues. Pepsin is produced in the stomach mucosa after
the proteolysis of proenzyme pepsinogen.
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