Literally meaning: "bones together”
Origin: Anc Greek
+ οστέον/osteoν(=bone) > ο (accumulate) + ίστημι/istimi(stand)
+(-ωσις)/(-osis )(=suffix denoting “process” or “state”)
In 1830, by AW Otto (1888-1895) who recognized the first premature closure of sutures as a discrete clinical entity.
Synostosis is the abnormal fusion of neighbor bones by the ossification of connecting tissues.