Term: creatine kinase or creatine phosphokinase (CPK)
Literally meaning: “enzyme of transfering energy chemical groupto creatine”
Origin: Anc Greek
κρέας/creas (flesh, meat)
+ίνη/-ine(-ine) = chemical suffix
+(-άση)/(-asy)(=-ase) enzyme suffix added to the name of the substrate that the enzyme hydrolyzes eg proteinase for protein or lipase for lipids
>διά-/dia-(=prefix denoting “through”, “apart” )
> δυο/dio(two) + στάσις/stasis(=halt) > ίστημι/histimi(=stand).
Creatine is an organic compound that serves as the energy storage form of cells mainly in muscle fibers. In 1835 French chemist and philosopher Michel-Eugene Chevreul (1786-1889) discovered it in the juice of flesh and named by him. Creatine kinase was first described by Lohmann in 1934 who showed in extracts of skeletal muscle the two labile phosphate groups of ATP were trransfererred to creatine. The reveraibility of the reaction was demonstrated by Lohmann (1935) and Banga in 1943 effected a partial purification of the enzyme .
1. Lohmann, K. (1934). Biochem. Z. 271, 264
2. Lehmann, H. (1935). Biochem. Z. 281, 271
(1943). Stud. Inst. med. Chem. Univ. Szeged, 8, 59
Creatine kinase (CK) is a kinase that converts creatine to phosphocreatine consuming ATP.