Term: epitope
Origin: Anc Greek
επί-/epi(=prefix meaning upon, on)
τόπος/topos(=place, location)
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| Niels Kaj Jerne (1911-1994) |
Coined: in 1960 by Danish immunologist Niels Kaj Jerne (1911–1994) who proposed that an antigen particle carries several epitopes.
Definition:
The surface portion of an antigen which is recognised by immune system (antibodies, B or T cells) and elicit an immune response. The part of an antibody that recognizes the epitope is called a paratope.
Sourses
Jerne, N.K. (1974), "Towards a network theory of the immune System", Ann. Immunol. (Paris
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