pharmacogenomics, pharmacogenetics

Origin: Anc Greek

φάρμακον/pharmakon (=medicine or poison)

γενετική/geneti(=genetics) or γενωμική/genomiki(=genomics)

>γενεά/ genea(=generation)

> γεννώ/geno (=birth to)

> γένεσις/genesis(=origin)

Coined:

Friedrich Vogel of Heidelberg (1925 – 2006)

The role of genetics in potentially causing adverse drug reactions was set out in 1957 paper with the programmatic title “Drug Reactions, Enzymes and Biochemical Genetics” (Motulsky, 1957). The term pharmacogenetics was coined finally in 1959 by German human geneticist  Friedrich Vogel of Heidelberg (1925 – 2006).

Sourse: Vogel F. Moderne problem der humangenetik. Ergeb Inn Med U Kinderheilk. 1959;12:52–125.

Definition

Pharmacogenetics and pharmacogenomics deal with the role of genetic factors in drug effectiveness and adverse drug reactions and they are used interchangeably. Pharmacogenetics is the study of genetic variation and metabolic pathways that gives rise to differing response to drugs Pharmacogenomics is the the study of drug response in the context of the entire genome.