Literally meaning: “separating elastin”
Origin: Anc Greek
Ελάω/elao(=be flexibe or ductile)) >ελαύνω/elavno(=run, drive)
-άση/-asy(=-ase) suffix added to the name of the substrate that the enzyme hydrolyzes eg proteinase for protein or lipase for lipids
>διά-/dia-(=prefix denoting “through”, “apart” )
> δυο/dio(two) + στάσις/stasis(=halt) > ίστημι/histimi(=stand).
in 1971 an elastolytic enzyme was defined first time which absorbs on elastin from Streptomyces griseus exhibiting specificity toward aminoacids with short aliphatic side chains (Gertler, 1971).
1.Gertler A, Hofmann T The involvement of the amino-terminal amino acid in the activity of pancreatic proteases. I. The effects of nitrous acid on elastase, J Biol Chem, 1967.
2. Gertlel A, Trop M The elastase-like enzymes from Streptomyces griseus (pronase).Isolation and partial characterization Eur J Bioch, 1971
Elastase is a proteolytic enzyme that is produced in pancreas, like trypsin, as an inactive proenzyme , and activated in duodenum by trypsin.