angiostatin

Term: angiostatin

Literally meaning: “protein of blocking blood vessels”

Origin: Anc Greek

αγγείο/angio(=vessel, receptacle) >  άγγος/aggos(=tube)

+ίστημι/histimi(=stand) >στάσις/stasis(=halt)

Coined/History 

Angiostatin was observed initially in 1994 as an angiogenesis inhibitor in serum and urine of mice bearing a Lewis lung carcinoma. The same research group  reffered that plasminogen yields distinct angiostatins which have been termed angiostatin -1 and angiostatin-2.

Sources

         O’Reilly M. S., Holmgren L., Shing Y., Chen C., Rosenthal R. A., Moses M. A.,       

            Lane W. S., Cao Y.,Sage E. H.,Folkman J. (1994) Cell 79:315–328

Definition

An endogenous protein that inhibits endothelial proliferation and was identified as an 38 kDa  internal fragment of plasminogen.