Literally meaning: “protein of blocking blood vessels”
Origin: Anc Greek
αγγείο/angio(=vessel, receptacle) > άγγος/aggos(=tube)
Angiostatin was observed initially in 1994 as an angiogenesis inhibitor in serum and urine of mice bearing a Lewis lung carcinoma. The same research group reffered that plasminogen yields distinct angiostatins which have been termed angiostatin -1 and angiostatin-2.
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An endogenous protein that inhibits endothelial proliferation and was identified as an 38 kDa internal fragment of plasminogen.