Term:annexin
Literally
meaning: “protein of bringing
together”
Origin: Anc Greek
ανά-/ana-(=prefix denoting up to, toward, against) >ανά/ana(=up, on, upon before, first)
(simple future) άξω/axo > άγω/ago (=bring, lead)
Coined/History
The name annexin was chosen to describe the principal
property nearly of all annexins i.e. the binding of certain biological
structures in membranes. They were discovered in the late 1970s and early 1980
and received diverse and unrelated names based on thheir biochemical properties
i.e synexin (for granule aggragating protein) or calpactins (proteins binding
Ca, phospholipid and actin).
The first study concerning annexiun was published in
1978 by Creutz et al, who identified
a calcium dependemt protein that was responsible for aggregation of granules
amongst each other and the plasma membrane. This protein was named synexin from
Greek word σύναξις/synaxis meaning meeting.
Sources
Creutz
Carl E. , Pazoles Christopher J., Pollard Harvey B. (April 1978). "Identification and purification of an adrenal
medullary protein (synexin) that causes calcium-dependent aggregation of
isolated chromaffin granules". Journal of Biological Chemistry 253 (8): 2858–66.
Definition
Annexin is a group of proteins which share a similar
gene structure and have a characteristic
70 amino acid repeat. All annexins are capable to bind negatively charged
phospholipids.
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