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chymotrypsin


Term: chymotrypsin
Literally meaning: “protein of rubbing juices
Origin: Greek
χυμός/chymos(=juice)   > χέω/cheo(=pour)
τρίβω/trivo (=rub, powder, grind) > (simple past) ἔτριψα /etripsα
Coined/History 
In 1934 M. Κunitz and J.H.Northrop were able to isolate and crystallize from pancreatic preparations an enzyme, in adition to trypsin, named chemotrypsin as well as the inactive precursor, chymotrypsinogen (J. Gen. Physiol., 17, 1934). Four years later Kunitz was able to isolate different active forms of the enzyme called them as alpha, beta, and gama. 
Definition
Chymothrepsin is a proteolytic enzyme that cleaves the peptide bonds at carboxy site of aromatic residues (tyrosine, phenylalanine, and tryptophan). Chymotrepsin is active in the intestine  produced by the acinar cells of the pancreas. Chymotrepsin becomes activated after proteolysis of chemotrypsinogen by trypsin. 

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