Term: chymotrypsin
Literally meaning: “protein of rubbing
juices”
Origin: Greek
χυμός/chymos(=juice)
> χέω/cheo(=pour)
+ τρίβω/trivo (=rub,
powder, grind) > (simple past) ἔτριψα /etripsα
Coined/History
In 1934 M. Κunitz and J.H.Northrop were able to isolate and
crystallize from pancreatic preparations an enzyme, in adition to trypsin,
named chemotrypsin as well as the inactive precursor, chymotrypsinogen (J. Gen. Physiol., 17, 1934). Four years
later Kunitz was able to isolate different active forms of the enzyme called
them as alpha, beta, and gama.
Definition
Chymothrepsin
is a proteolytic enzyme that cleaves the peptide bonds at carboxy site of
aromatic residues (tyrosine, phenylalanine, and tryptophan). Chymotrepsin is
active in the intestine produced by the
acinar cells of the pancreas. Chymotrepsin becomes activated after proteolysis
of chemotrypsinogen by trypsin.
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