Term: angiogenin
(Ang-1) or ribonuclease 5
Literally meaning: “that produces vessels”
Origin: Anc Greek
αγγείο/aggio
(=vessel, receptacle) > άγγος/aggos(=tube)
+γεννώ/geno(=
“produce”, “give birth to”, “create”)
Coined/History
The term angiogenesis was
coined by Arthur T. Hertig in 1935 to describe the formation of new blood
vessels in the placenta. Angiogenin was named the first angiogenesis factor to be isolated in
pure form from human sources (colorectal
adenocarcinoma cell line HT-29).
Sources
Hertig
AT. Angiogenesis in the early human chorion and in the primary placenta of the
macaque monkey. Contr Embryol Carnegie Inst. 1935;25:37–81.
Strydom DJ, Fett JW, Lobb RR, Alderman EM, Bethune JL, Riordan JF, Vallee BL.Amino acid sequence of
human tumor derived angiogenin.Biochemistry. 1985 Sep
24;24(20):5486-94.
Definition
Angiogenin is coded by ANG gene and acts as ribuneclease of
tRNAs and a potent stimulator of
endothelial cells. Although angiogenin is not a tumour specific protein (123 aa),
it was the first angiogenic protein to be isolated from human tumour cells. It
is characterised by its capacity for neovasscularization not only in tumors but
also in healthy tissues.
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